Chick Chorioallantoic Membrane as an In Situ Biological Membrane for Pharmaceutical Formulation Development: A Review

The use of animals in research has always been a debatable issue. Over the past few decades, efforts have been made to reduce, replace, and refine experiments for ethical use of experimental animals. The use of chick chorioallantoic membrane (CAM) was one of the proposed alternatives to the Draize rabbit ocular irritation test with several advantages including simplicity, rapidity, sensitivity, ease of performance, and cost-effectiveness. The recent use of CAM in the development of pharmaceuticals and testing models to mimic human tissue, including drug transport across CAM, will be discussed in this review.     

Adolescents' explanations for political issues: Concordance with their views of self and society.

The relationships between adolescents' explanations for unemployment, poverty, and homelessness and their beliefs about opportunity, reports of family values, and personal aspirations were tested for 434 teenagers (mean age?=?16 years 4 months). Explanations were coded for references to individual causes, societal causes, or both. Higher maternal education and average household income in the adolescent's school district were positively related to the likelihood of attributing all three problems to societal causes. When explaining unemployment, older adolescents noted both causes, and boys mentioned individual factors whereas girls mentioned societal factors. After adjustment for background factors, those endorsing individual causes were more likely to believe that all Americans enjoyed equal opportunity and that government support encouraged dependency, and they were more committed to materialist goals. In contrast, youth endorsing societal or situational causes had more altruistic life goals and reported that compassion was emphasized in their families. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Social organization,constraints and opportunities for kitchen garden implementation: ScalA and ScalA-FS assessment tools in Morogoro and Dodoma,Tanzania

Tanzania is the second largest country in East Africa with about 50 million inhabitants in 2014, and it is also considered as one of the poorest countries in the world. The country strongly depends on agriculture production. Like many other poor countries in sub-Saharan Africa, Tanzania sees food security as a central part of development and poverty reduction efforts. This work aims to investigate the opportunities and constraints of implementing a policy of “Kitchen Gardens” as a practice for two regions of Tanzania. The research was carried out with a qualitative approach through a first round of semi-structured interviews using a Scaling up Assessment Tool (ScalA), and a second round with a questionnaire survey, using a Scaling up Assessment Tool for Food Security (ScalA-FS) by Tanzanian and German experts from the Trans-SEC project. The experts assessed implementation suitability and the institutional requirements of Kitchen Garden across the food value chains in two Tanzanian regions with different climate regions, namely Dodoma (semi-arid) and Morogoro (sub-humid). Kitchen Garden assessments did not differ significantly between these regions. The ScalA tools provided a range of statements that allowed an overview of the structural situation to be obtained, which could enable Kitchen Garden activity to be incentivized and scaled up. However, a number of specific aspects, potentials, challenges, and likely bottlenecks of implementation related to their feasibility and institutional requirements, were indicated, which should be carefully monitored during implementation. Adopting the recommended strategies could help to close gaps in implementation, enhance community empowerment and social network development, reduce food insecurity and improve the health of the communities.     

Depression and sensitization to stressors among young women as a function of childhood adversity.

The authors tested a stress-sensitization version of a diathesis-stress approach to depression. In a 2-year longitudinal follow-up design, exposure to stressful life events was examined in young women in the transition to adulthood. The authors hypothesized that those who had experienced one or more significant childhood adversities would have a lower threshold for developing a depressive reaction to stressors. Results indicated that women with exposure to one or more childhood adversities—such as family violence, parent psychopathology or alcoholism, and others—were more likely to become depressed following less total stress than women without such adversity. The results could not be accounted for by chronic stress or prior depression. Both biological and psychological sensitization mechanisms may be speculated to play a role, but the actual mechanisms of stress sensitization remain to be explored. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Improved estimation of the resistivity of pure copper and electrical determination of thin copper film dimensions

Improved values for the resistivity, ρ, of pure, bulk copper from 50 to 1200 K, and their confidence intervals, are developed by extending the analysis of Matula. A recommended value for dρ/dT and its confidence interval in the temperature range of 290–425 K is developed for use with Matthiessen's rule to calculate the electrical thickness of thin copper films and the cross-sectional area of copper lines from resistance measurements at two temperatures. Error analyses are used to estimate the uncertainty with which the electrical thickness and cross-sectional area can be determined. Values for the temperature coefficient of resistance of pure, bulk copper are also provided.     

Role of maternal depression in perceptions of child maladjustment.

We investigated (a) the relation of maternal depression to perceptions of externalizing and internalizing disorders in children and (b) quality of communication in a mother–child interaction task as a function of maternal depression and perceptions of the child. 64 children of unipolar or bipolar mothers, chronic medically ill or normal mothers were studied; clinical diagnoses, children's reports, and teachers' ratings served as objective criteria of children's maladjustment. Maternal depression defined by current symptomatology on the Beck Depression Inventory and by psychiatric status was not associated with misperceptions of psychopathology. Maternal depression interacted with children's actual behaviors to predict mothers' perceptions: nondepressed mothers were less accurate reporters of problems in children than were depressed mothers. Depressed mothers who perceived maladjustment in their disturbed children made more negative comments in interactions than did nondepressed mothers of disturbed children. The apparent mutual impact of mothers' and children's maladjustment requires fuller exploration in offspring studies. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

AIDS: Ethical implications for psychological intervention.

Examines the ethical issues facing psychologists working with people who are infected with AIDS (acquired immune deficiency syndrome) and individuals in high-risk groups. Duty to treat is examined with a consideration of homophobia and biases about intravenous drug users. Confidentiality is discussed in the context of record keeping, in cases of conflict with duty to warn, and in cases of suicide. Psychologists are urged to consider possible ethical dilemmas before they arise, to ensure that the best decisions are made. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Initial symptom levels and the life-event–depression relationship.

93 undergraduates selected for diversity of initial depression levels were studied longitudinally to explore the relation between stressful events and depression. Ss were chosen on the basis of their scores on an information-processing procedure, the Beck Depression Inventory, the Schedule for Affective Disorders and Schizophrenia—Lifetime Version, and the SCL-90. After the initial screening, Ss completed a 2-hr interview covering current and lifetime diagnostic status and stressful life-event occurrence in the previous 12 mo. Following this, they participated in 4 regular monthly follow-ups. Regression analyses and inspection of individual patterns supported the hypothesis that initial depression status is a critical factor in depression–event associations and that concurrent high-impact negative events contribute significantly but modestly to outcomes. It appeared that nonsymptomatic Ss were relatively resistant to onset even when exposed to high-impact stress events, whereas a subset of initially symptomatic Ss continued to have both more depression and more high-impact events over time. It is suggested that future research on event–depression associations should carefully consider these different outcome patterns: symptom resistance and symptom onset in nondepressed persons and symptom remission and symptom maintenance or recurrence in initially depressed persons. (43 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

School and community climates and civic commitments: Patterns for ethnic minority and majority students.

The developmental correlates of diffuse support for the polity and civic commitments were explored in a survey of 1,052 students (mean age = 14.96 years) from African American, Arab American, European American, and Latino American backgrounds. Results of structural equation modeling revealed that regardless of their age, gender, or ethnic background, youth were more likely to believe that America was a just society and to commit to democratic goals if they felt a sense of community connectedness, especially if they felt that their teachers practiced a democratic ethic at school. Discussion focuses on the civic purposes of education in inculcating a sense of identification with the polity in younger generations. (PsycINFO Database Record (c) 2010 APA, all rights reserved)